Role of FGF-18 in Bone Regeneration
Kavipriya Murugaiyan1, Sivashanmugam Amirthalingam2, Nathaniel Suk-Yeon Hwang2,3,4,5
1Polymeric Biomaterials Lab, School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
Journal of Functional Biomaterials
|January 20, 2023
Summary
Fibroblast Growth Factor-18 (FGF-18) shows promise in bone regeneration by promoting osteoblast differentiation and bone formation. Incorporating FGF-18 into scaffolds enhances its effectiveness in tissue engineering applications.
Area of Science:
- Tissue Engineering
- Biomaterials Science
- Regenerative Medicine
Background:
- Tissue engineering relies on cells, cues, and scaffolds for regeneration.
- Growth factors, including Fibroblast Growth Factors (FGFs), are critical biological cues.
- FGF-18 has emerged as a key factor in osteoblast differentiation and bone regeneration.
Purpose of the Study:
- To review the functions of FGF-18 in bone regeneration.
- To highlight current trends and potential outcomes of using FGF-18 in tissue engineering.
Main Methods:
- Review of scientific literature on FGF-18 and bone regeneration.
- Analysis of FGF-18's role in cellular pathways (PI3K/ERK, smad1/5/8).
- Examination of FGF-18 delivery systems like hydrogels and scaffolds.
Main Results:
- FGF-18 promotes osteoblast differentiation and bone formation.
- FGF-18 stimulates key signaling pathways (PI3K/ERK, smad1/5/8) essential for bone development.
- FGF-18 incorporated into hydrogels and scaffolds demonstrated enhanced bone regeneration.
Conclusions:
- FGF-18 is a significant growth factor for bone regeneration.
- Optimized delivery systems for FGF-18 can improve tissue engineering outcomes.
- Further research into FGF-18 holds potential for advancing bone defect treatments.
Keywords:
bone regenerationfibroblasticgrowth factors (FGF)osseoconductionosseoinductionosseointegrationosteogenesisscaffoldsMore Related Videos
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