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Gametic disequilibrium measures: proceed with caution.

P W Hedrick1

  • 1Department of Genetics, University of California, Berkeley 94720.

Genetics
|October 1, 1987
PubMed
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This study compares five gametic disequilibrium measures, finding the new D' measure most reliable. It is less dependent on allele frequencies and shows lower variance, avoiding mistaken conclusions in population genetics studies.

Area of Science:

  • Population Genetics
  • Evolutionary Biology
  • Molecular Ecology

Background:

  • Gametic disequilibrium (GD) is crucial for understanding genetic linkage and population structure.
  • Existing GD measures often exhibit frequency dependence and limitations in interpretation.

Purpose of the Study:

  • To evaluate five current gametic disequilibrium measures and introduce a novel measure based on Lewontin's D'.
  • To compare the performance and reliability of these measures under various population genetic conditions.

Main Methods:

  • Comparative analysis of five established gametic disequilibrium measures.
  • Introduction and evaluation of a new measure derived from Lewontin's D'.

Main Results:

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  • Most existing measures are highly dependent on allele frequencies, even when normalized.
  • The novel D'-based measure demonstrated lower variance and reduced frequency dependence compared to others.
  • Several measures showed negative values at maximum disequilibrium and variable decay rates, complicating interpretation.

    • Conclusions:

    • The new D'-based measure offers a more robust and reliable assessment of gametic disequilibrium.
    • Reliance on frequency-dependent measures can lead to erroneous conclusions regarding recombination and population history.