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Action of some amides of substituted ethylenediamines on central nervous system
O P Sethi1, A M Ismail, G C Bhavsar
1Department of Pharmacology, L.M. College of Pharmacy, Navarangpura, Ahmedabad.
Indian Journal of Physiology and Pharmacology
|April 1, 1987
Abstract:
Five of the substituted ethylenediamine amides (LMG I to V) were tested for various CNS attributes and for acute toxicity (24 hr mortality). All compounds were potent analgesics in various animal tests, LMG V being most potent. All reduced spontaneous activity of mice and potentiated ether anaesthesia. However, CAR was not altered and anti-MES were not pronounced in rats. Compounds appear to have a wide safety margin considering ED50 and LD50 in mice.