Upon the nature of Hodgkin's disease and the Reed-Sternberg cell

Immunoglobulin components have been demonstrated within Reed-Sternberg cell in Hodgkin's disease using immunoperoxidase techniques. The possibility that this finding is indicative of a B-lymphocytic origin for the Reed-Sternberg cell is considered, and the implications that such a conclusion might have regarding the histiopathology of Hodgkin's disease and the relationship of Hodgkin's disease to other lymphomas is discussed.