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Effect of verapamil on pulmonary function changes induced by fluid overloading in normal subjects
S Baldi1, E Scappaticci, F Coni
1Service of Respiratory Physiopathology, Molinette Hospital, Turin, Italy.
International Journal of Clinical Pharmacology Research
|January 1, 1987
Summary
Verapamil may prevent breathing problems caused by fluid overload. This study found verapamil administration blunted respiratory function abnormalities from rapid saline infusion in normal subjects.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Pharmacology
Background:
- Rapid intravenous fluid administration can cause pulmonary function abnormalities.
- Interstitial lung edema is a potential complication of fluid overload.
Purpose of the Study:
- To investigate the acute effects of verapamil on pulmonary function during rapid saline infusion.
- To determine if verapamil can mitigate respiratory changes associated with fluid overloading.
Main Methods:
- Six healthy subjects received intravenous verapamil (10 mg).
- Pulmonary function, specifically closing volume, was measured before and after rapid saline infusion.
- Changes in closing volume were compared with and without verapamil administration.
Main Results:
- Rapid saline infusion significantly increased closing volume (p < 0.05).
- Following verapamil administration, the increase in closing volume after infusion was not significant in three subjects.
- The mean increase in closing volume was significantly blunted after verapamil treatment.
Conclusions:
- Intravenous verapamil appears to mitigate acute respiratory function abnormalities induced by rapid fluid overload.
- Verapamil may have a protective role against the development of interstitial lung edema during overhydration.
- These findings suggest a potential therapeutic application for verapamil in managing fluid-induced respiratory distress.