Related Experiment Video
Updated: Aug 13, 2025
04:25
Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies
Published on: December 15, 2023
2.6K
Genetic Predisposition to Neurological Complications in Patients with COVID-19
Nikhil Shri Sahajpal1,2, Alex R Hastie3, Maximilian Schieck4,5
1Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Biomolecules
|January 21, 2023
Summary
Genetic factors may predispose individuals to neurological complications from COVID-19. Researchers identified unique structural variants (SVs) linked to neurological issues in patients with severe COVID-19, suggesting a potential genetic basis.
Area of Science:
- Genetics
- Neurology
- Infectious Diseases
Background:
- While genetic variants linked to severe COVID-19 are known, their role in neurological complications remains unexplored.
- Neurological manifestations are a significant concern in COVID-19 patients.
Purpose of the Study:
- To investigate potential genetic determinants predisposing individuals to COVID-19-associated neurological complications.
- To identify specific genetic variants associated with neurological symptoms in COVID-19 patients.
Main Methods:
- Analysis of rare/unique structural variants (SVs) in two individuals presenting with neurological manifestations of COVID-19.
- Focus on SVs implicated in neurological functions.
Main Results:
- Identification of rare/unique structural variants (SVs) associated with neurological functions in the studied individuals.
- These SVs are implicated in patients experiencing neurological symptoms alongside COVID-19.
Conclusions:
- This report suggests a possible genetic link between specific structural variants and neurological complications in COVID-19.
- Further research on larger cohorts is warranted to confirm the genetic predisposition to COVID-19-related neurological conditions.
More Related Videos
Related Concept Videos
01:28Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
01:29Biological Causes of Schizophrenia
114
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
114
01:28Human Genetics
658
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
658
01:29Genetic Disorders
12
Genetic DisorderGenetic disorders are diseases or conditions caused by changes in an individual's DNA. These changes, known as mutations, can be inherited from parents or occur randomly during a person’s life. Some genetic disorders, such as sickle cell anemia and cystic fibrosis, result from single-gene mutations, while others, like Down syndrome, are caused by chromosomal abnormalities. Understanding genetic disorders helps scientists develop medical treatments, improve genetic counseling,...
12
01:05Single Nucleotide Polymorphisms-SNPs
15.5K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.5K
01:23Cystic Fibrosis: Pathogenesis
323
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
323