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Published on: March 20, 2015
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Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review.
K A Esther Jebakumari1,2, N K Murugasenapathi1,2, Tamilarasan Palanisamy1,2
1Electrodics and Electrocatalysis Division (EEC), CSIR-Central Electrochemical Research Institute (CECRI), Karaikudi 630003, Tamil Nadu, India.
Biosensors
|January 21, 2023
Summary
Two-dimensional nanostructures (2DNS) are revolutionizing biomolecule sensing with Surface-Enhanced Raman Scattering (SERS) substrates. This review explores engineered 2DNS-SERS for enhanced detection in complex biological samples.
Area of Science:
- Materials Science
- Nanotechnology
- Analytical Chemistry
Background:
- Two-dimensional nanostructures (2DNS) offer high surface-to-volume ratios and tunable properties, making them promising for applications like biomolecule sensing.
- Surface-Enhanced Raman Scattering (SERS) is a highly sensitive, non-destructive technique ideal for analyzing trace amounts of analytes.
- Engineered 2DNS are being developed as advanced SERS substrates to overcome limitations of traditional plasmonic materials.
Purpose of the Study:
- To review recent advancements in engineered two-dimensional nanostructures (2DNS) for Surface-Enhanced Raman Scattering (SERS) based biomolecule sensing.
- To survey the use of 2DNS as standalone enhancers or supports for plasmonic nanostructures in SERS applications.
- To critically assess current challenges and future opportunities in developing 2DNS-SERS for biomolecule detection in complex matrices.
Main Methods:
- Systematic survey of recent literature on engineered 2DNS for SERS substrates.
- Analysis of 2DNS applications as standalone signal enhancers in SERS.
- Evaluation of 2DNS as support materials for plasmonic nanostructures in SERS.
Main Results:
- Engineered 2DNS, including those with π-π* interactions, show significant potential for biomolecule sensing.
- 2DNS can function effectively either independently or in synergy with plasmonic nanoparticles to enhance SERS signals.
- Recent developments focus on tailoring 2DNS properties for improved sensitivity and specificity in complex biological fluids.
Conclusions:
- Engineered 2DNS represent a significant advancement in SERS substrate design for sensitive biomolecule detection.
- The combination of 2DNS with plasmonic nanostructures offers synergistic benefits for enhanced sensing capabilities.
- Further research into novel 2DNS materials and fabrication techniques is crucial for realizing their full potential in diagnostics.
