Related Experiment Video

Updated: Aug 13, 2025

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
06:07

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Pharmacomicrobiomics in Anticancer Therapies: Why the Gut Microbiota Should Be Pointed Out

Gabriele Conti1,2, Federica D'Amico1,2, Marco Fabbrini1,2

  • 1Microbiomics Unit, Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.

Genes
|January 21, 2023
PubMed

Insights

The gut microbiota significantly impacts cancer treatment outcomes. Understanding these interactions is key to developing personalized therapies and improving patient results through microbiota modulation.

Area of Science:

  • Oncology
  • Microbiology
  • Pharmacology

Background:

  • Gut microbiota influences cancer pathology and treatment efficacy.
  • Mechanisms of microbiota-drug interactions in oncology are not fully understood.

Purpose of the Study:

  • To review the relationship between gut microbiota and common anticancer drugs.
  • To explore strategies for optimizing cancer treatment through microbiota manipulation.

Main Methods:

  • Literature review of microbiota-drug interactions in cancer.
  • Discussion of prebiotics, probiotics, antibiotics, and fecal microbiota transplantation.
  • Brief overview of tumor-associated bacteria in cancer therapy.

Main Results:

  • Gut microbiota activity can affect anticancer treatment outcomes.
  • Various strategies exist to modulate the gut microbiota for improved clinical results.
  • Exploiting tumor-associated bacteria offers novel therapeutic avenues.

Conclusions:

  • Further research using multi-omics and AI is crucial for personalized cancer therapies.
  • Understanding host-microbiota-drug interactions will advance precision oncology.
  • Targeted microbiota modulation holds promise for enhancing cancer treatment efficacy.
Keywords:
anticancer drugsgut microbiotagut microbiota modulationmicrobiome-derived metabolismmulti-omicspharmacomicrobiomicstumor microenvironmenttumor-associated bacteria

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