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The Interaction between Flavonoids and Intestinal Microbes: A Review
Hui-Hui Xiong1, Su-Yun Lin1, Ling-Li Chen1
1College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
Foods (Basel, Switzerland)
|January 21, 2023
Summary
Flavonoids interact with gut microbes, influencing health and disease. This bidirectional relationship impacts flavonoid metabolism and health outcomes, offering insights into treating diseases like obesity and cancer.
Area of Science:
- Food Science
- Nutriology
- Biomedicine
Background:
- Gut microbiota is crucial for intestinal homeostasis and health.
- Dysregulation of gut microbiota is linked to various diseases.
- Flavonoids possess physiological activities and are transformed by gut microbiota.
Purpose of the Study:
- To review the interaction between flavonoids and gut microbiota.
- To understand how flavonoids regulate diseases via gut microbiota.
- To explore the bidirectional relationship between microbiota and flavonoids.
Main Methods:
- Literature review focusing on microbiota-flavonoid interactions.
- Analysis of flavonoid metabolism and biotransformation by gut microbes.
- Discussion of mechanisms influencing gut barrier function and immunity.
Main Results:
- Gut microbiota metabolizes flavonoids into health-promoting compounds.
- Microbiota-flavonoid interactions affect bioavailability and bioactivity.
- Flavonoids modulate gut microbiota composition and diversity.
Conclusions:
- The bidirectional interaction between flavonoids and gut microbiota is key to health.
- Understanding this interaction provides a basis for treating gastrointestinal diseases, obesity, diabetes, and cancer.
- Flavonoids protect intestinal barrier function and the immune system through microbiota modulation.
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