Gastrointestinal zygomycosis in suckling pigs

Gastrointestinal zygomycosis was diagnosed in 3 suckling pigs (10, 14, and 28 days old) with diarrhea that was unresponsive to treatment with broad-spectrum antibiotics. The 3 pigs were from separate farms, and littermates of the 3 pigs with similar clinical signs had died. At necropsy, 2 of the 3 pigs had catarrhal to fibrinonecrotic gastroenteritis, and the third pig had hemorrhagic gastritis without intestinal lesions. Microscopically, transmural necrosis of the stomach and intestines was associated with marked inflammatory cell infiltration and thrombosis and vasculitis of vessels of the lamina propria and submucosa. Numerous broad, irregularly branching, nonseptate, mucoraceous fungi were seen in the lumens of blood vessels and in the necrotic mucosa and submucosa.