Related Experiment Video

Updated: Aug 13, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

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Molecular Mechanisms of Noncoding RNA in the Occurrence of Castration-Resistant Prostate Cancer

Yu Lin1, Haisong Tan1, Guopeng Yu1

  • 1Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

International Journal of Molecular Sciences
|January 21, 2023
PubMed

Insights

Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), play a key role in the development of castration-resistant prostate cancer (CRPC). Understanding these ncRNAs offers new diagnostic and therapeutic strategies for CRPC patients.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Prostate cancer progression to castration-refractory prostate cancer (CRPC) remains a clinical challenge.
  • CRPC is a heterogeneous disease with complex underlying mechanisms.
  • Noncoding RNAs (ncRNAs) are implicated in various biological processes relevant to cancer.

Purpose of the Study:

  • To review recent findings on the role of ncRNAs in CRPC.
  • To discuss the functional mechanisms of ncRNAs in CRPC development.
  • To highlight the clinical application prospects of ncRNAs in CRPC.

Main Methods:

  • Literature review of recent scientific findings.
  • Analysis of the role of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in CRPC.
  • Discussion of molecular mechanisms and clinical relevance.

Main Results:

  • ncRNAs, particularly miRNAs and lncRNAs, are closely linked to CRPC progression.
  • These ncRNAs influence critical cancer pathways including metabolism, epigenetics, and immune evasion.
  • ncRNAs show potential as biomarkers for CRPC diagnosis and prognosis.

Conclusions:

  • ncRNAs are crucial regulators in the development and progression of CRPC.
  • Targeting ncRNAs may offer novel therapeutic strategies for CRPC.
  • ncRNAs hold significant promise as diagnostic and prognostic biomarkers for CRPC.
Keywords:
androgen receptorcastration-resistant prostate cancerepigenetic modificationslong non-coding RNAsmicro RNAstumor metabolisms

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