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Quantification of Plasmid-Mediated Antibiotic Resistance in an Experimental Evolution Approach
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Quantifying In-Host Quasispecies Evolution.

Josep Gregori1, Marta Ibañez-Lligoña1,2,3, Josep Quer1,2,3

  • 1Liver Diseases-Viral Hepatitis, Liver Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

International Journal of Molecular Sciences
|January 21, 2023
PubMed
Summary
This summary is machine-generated.

Viral quasispecies evolve rapidly, mirroring ecosystem changes over months instead of millennia. New indices quantify this evolution by tracking haplotype frequencies, offering insights into viral dynamics and treatment responses.

Keywords:
distributions similaritymutagenesisquasispecies evolutionquasispecies fitness partitionviral treatment

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Area of Science:

  • Virology
  • Evolutionary Biology
  • Computational Biology

Background:

  • Viral quasispecies exhibit rapid evolution, compressed into days or months compared to natural ecosystems' millennia.
  • Understanding viral evolution is crucial, especially during host treatment, where evolutionary rates accelerate.

Purpose of the Study:

  • To introduce and discuss novel methods for quantifying viral quasispecies evolution.
  • To provide simulated examples for interpreting evolutionary analysis results.
  • To demonstrate the utility of proposed indices in a clinical setting.

Main Methods:

  • Conceptualizing viral quasispecies as ecosystems with competing haplotypes (species).
  • Quantifying evolution by monitoring changes in haplotype frequencies over time.
  • Developing and correlating novel indices to measure evolutionary dynamics.

Main Results:

  • Simulated examples illustrate the interpretation of evolutionary indices.
  • The proposed indices effectively quantify viral evolution dynamics.
  • Correlation analysis between indices provides a comprehensive understanding of evolutionary patterns.

Conclusions:

  • The developed methods offer a robust framework for analyzing viral quasispecies evolution.
  • The proposed indices are valuable tools for understanding rapid evolutionary processes in viruses.
  • Application to a clinical case highlights the practical relevance of these evolutionary insights.