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Related Experiment Video

Updated: Aug 13, 2025

Expression, Purification, and Antimicrobial Activity of S100A12

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

S100A6 Protein-Expression and Function in Norm and Pathology.

Wiesława Leśniak¹, Anna Filipek¹

¹Laboratory of Calcium Binding Proteins, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.

International Journal of Molecular Sciences

|January 21, 2023

Summary

S100A6 (calcyclin) is a calcium-binding protein involved in various cellular processes. Its altered expression in diseases like cancer highlights its pathological significance and role in disease progression.

Keywords:

S100A6 (calcyclin)body fluids expression intracellular/extracellular role marker pathology stem/progenitor cells tumors

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Area of Science:

Biochemistry
Molecular Biology
Cell Biology

Background:

S100A6 (calcyclin) is a calcium-binding protein within the S100 protein family, identified over 30 years ago.
Early research focused on its calcium-binding properties and conformational changes, later expanding to expression, localization, and binding partners.

Purpose of the Study:

To review current knowledge on S100A6 biology, including its expression, localization, and interactions.
To summarize S100A6's role in calcium-dependent cellular processes and its association with various pathologies.

Main Methods:

Literature review of biophysical studies, structural analyses, and research on S100A6 expression and function.
Analysis of data linking S100A6 to disease states, particularly cancers.

Main Results:

S100A6 structure and its complexes with ligands have been elucidated using biophysical methods.
Altered S100A6 expression correlates with disease progression, suggesting a causative role in some pathologies.
The list of S100A6 ligands and understanding of its physiological importance are continually expanding.

Conclusions:

S100A6 plays a significant role in cellular processes and disease pathogenesis.
Further research is needed to fully understand the mechanisms of S100A6 action and its therapeutic potential.