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Radiometric-high-performance liquid chromatographic assay for nicotine and twelve of its metabolites
G A Kyerematen1, L H Taylor, J D deBethizy
1Department of Pharmacology, Pennsylvania State University, College of Medicine, Hershey 17033.
Journal of Chromatography
|August 7, 1987
Abstract:
A sensitive, reproducible radiometric-high-performance liquid chromatographic assay has been developed to measure concentrations of nicotine and twelve of its metabolites in biological fluids. Following administration of nicotine ([2-14C]pyrrolidine) to rats, the assay was used in a pharmacokinetic investigation.