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In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application

Aleksandra Krstevska1,2, Jelena Đuriš1, Svetlana Ibrić1

  • 1Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia.

Pharmaceutics
|January 21, 2023
PubMed
Summary

Physiologically based pharmacokinetic (PBPK) modeling is increasingly applied in drug discovery and development. This review analyzes PBPK applications, revealing its use in early development, risk assessment, and predicting interactions, though model validation is less frequently reported.

Keywords:
modeling and simulations (M&S)physiologically based biopharmaceutics modeling (PBBM)physiologically based pharmacokinetic modeling (PBPK)text miningtopic modeling

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