Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

45.1K
Overview
45.1K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

156
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
156
Cancer Vaccines01:30

Cancer Vaccines

475
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
475
Immunological Memory01:23

Immunological Memory

2.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
2.7K
Cross-reactivity00:42

Cross-reactivity

31.4K
Overview
31.4K
Active versus Passive Immunity01:31

Active versus Passive Immunity

2.3K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

99th-Percentile Upper Reference Limit for the New Snibe High-Sensitivity Troponin I Assay in a Southeast Asian Population.

Diagnostics (Basel, Switzerland)·2025
Same author

Analytical Performance of the New Sysmex High-Sensitivity Troponin T Assay.

Diagnostics (Basel, Switzerland)·2025
Same author

Thalassemia traits may modulate protective mir-155 levels in dengue infection.

Medical microbiology and immunology·2025
Same author

Reflections on COVID-19: A Literature Review of SARS-CoV-2 Testing.

Vaccines·2025
Same author

Emerging Role of Natriuretic Peptides in Diabetes Care: A Brief Review of Pertinent Recent Literature.

Diagnostics (Basel, Switzerland)·2024
Same author

Effects of Oral Nutritional Supplement with β-Hydroxy-β-methylbutyrate (HMB) on Biochemical and Hematological Indices in Community-Dwelling Older Adults at Risk of Malnutrition: Findings from the SHIELD Study.

Nutrients·2024
Same journal

Correction: Fukushima et al. Long-Term Immunogenicity of Rabies Pre-Exposure Prophylaxis in Japanese Adult Travelers: Comparison of Dosing Regimens. <i>Vaccines</i> 2025, <i>13</i>, 1169.

Vaccines·2026
Same journal

Access to Vaccines Among Asylum Seekers, Refugees, and Undocumented Migrants Across the Migratory Cycle in the European Union, European Economic Area, Switzerland and the United Kingdom: A Scoping Review.

Vaccines·2026
Same journal

Advances in Detection Methods for Human Respiratory Syncytial Virus Neutralizing Antibodies.

Vaccines·2026
Same journal

Insights from 25 Years of Measles and Measles-Rubella Vaccination Campaigns in the WHO African Region (2001-2025).

Vaccines·2026
Same journal

Post-Marketing Safety Surveillance of Influenza Vaccines in Anhui Province, China, 2016-2025.

Vaccines·2026
Same journal

Characteristics of Hypotonic-Hyporesponsive Episodes (HHEs) Following Childhood Vaccination: A 13-Year Analysis of Spontaneous Reports to the Dutch Pharmacovigilance Centre Lareb.

Vaccines·2026
See all related articles

Related Experiment Video

Updated: Aug 13, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.8K

Considerations in Understanding Vaccine Effectiveness.

Chin Shern Lau1, Tar Choon Aw1,2,3

  • 1Department of Laboratory Medicine, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore.

Vaccines
|January 21, 2023
PubMed
Summary
This summary is machine-generated.

Interpreting SARS-CoV-2 vaccine effectiveness requires considering antibody waning, viral variants, and disease prevalence. These factors significantly influence how we understand vaccine performance and disease prevention strategies.

Keywords:
COVID-19SARS-CoV-2prevalencevaccine effectiveness

More Related Videos

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.3K
In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
09:04

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

Published on: May 11, 2020

12.7K

Related Experiment Videos

Last Updated: Aug 13, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.8K
Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.3K
In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
09:04

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

Published on: May 11, 2020

12.7K

Area of Science:

  • Immunology
  • Epidemiology
  • Public Health

Background:

  • Vaccine effectiveness reports are crucial for evaluating SARS-CoV-2 vaccination policies.
  • Accurate interpretation of these reports is challenged by several dynamic factors.

Purpose of the Study:

  • To analyze the impact of key factors on the interpretation of SARS-CoV-2 vaccine effectiveness.
  • To enhance understanding of how vaccines contribute to disease prevention.

Main Methods:

  • Review of existing literature on vaccine effectiveness studies.
  • Analysis of the influence of antibody waning, viral variants, and disease prevalence on reported effectiveness.
  • Examination of the interplay between relative and absolute risk reduction.

Main Results:

  • Antibody waning can decrease protection over time.
  • Emerging viral variants may evade vaccine-induced immunity.
  • Disease prevalence significantly affects the calculation of absolute risk reduction, potentially skewing efficacy interpretation.

Conclusions:

  • A comprehensive approach is necessary for interpreting SARS-CoV-2 vaccine effectiveness.
  • Considering waning immunity, viral evolution, and population disease levels is vital for accurate assessment.
  • This understanding is key to optimizing vaccination strategies for improved public health outcomes.