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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
502
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Comorbid Asthma Increased the Risk for COVID-19 Mortality in Asia: A Meta-Analysis.

Liqin Shi1, Jiahao Ren1, Yujia Wang2

  • 1Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.

Vaccines
|January 21, 2023
PubMed
Summary

Comorbid asthma significantly increases the risk of mortality in coronavirus disease 2019 (COVID-19) patients across Asia. This meta-analysis highlights asthma as a critical factor in COVID-19 outcomes in the Asian population.

Keywords:
Asiaasthmacoronavirus disease 2019meta-analysismortality

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Area of Science:

  • Epidemiology
  • Public Health
  • Respiratory Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) has posed a significant global health threat.
  • The impact of comorbid conditions on COVID-19 mortality requires thorough investigation.
  • Asthma is a prevalent chronic respiratory disease with potential implications for infectious disease severity.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between comorbid asthma and mortality risk in COVID-19 patients in Asia.
  • To quantify the pooled odds ratio (OR) for mortality among COVID-19 patients with asthma.

Main Methods:

  • Systematic search of electronic databases for eligible studies.
  • Meta-analysis of 103 studies involving 198,078 COVID-19 patients.
  • Random-effect model used for estimating pooled OR and 95% confidence intervals (CI); heterogeneity assessed using I2 statistic.

Main Results:

  • Comorbid asthma was significantly associated with increased COVID-19 mortality risk in Asia (pooled OR = 1.42, 95% CI: 1.20−1.68).
  • Statistical heterogeneity was observed (I2 = 70%, p < 0.01), with meta-regression suggesting male proportion as a potential source.
  • Subgroup analyses and sensitivity analyses confirmed the robustness of the findings; no significant publication bias was detected.

Conclusions:

  • COVID-19 patients in Asia with comorbid asthma face a higher risk of mortality.
  • Findings are particularly relevant for non-elderly individuals, suggesting asthma as a key risk factor.
  • Further research into the mechanisms underlying this increased mortality risk is warranted.