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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Updated: Aug 13, 2025

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

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Biological skin regeneration using epigenetic targets.

Fahad Hussain Mohammed1, Franz Cemic2, Jürgen Hemberger2

  • 1Biomedical and Biotechnological Center (BBZ), University of Leipzig, Leipzig, Germany; Institute of Biochemical Engineering & Analysis, University of Applied Sciences, Giessen, Germany.

Drug Discovery Today
|January 21, 2023
PubMed
Summary
This summary is machine-generated.

Epigenetic targets offer a new frontier for skin regeneration drugs. Targeting epigenetic mechanisms like DNA methylation and histone modification shows promise in preclinical and clinical trials for improved skin health.

Keywords:
DNA methylationDNMTEGFRHDACTGF-βVEGFepigeneticsmiR

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Last Updated: Aug 13, 2025

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Epigenetic Conversion as a Safe and Simple Method to Obtain Insulin-secreting Cells from Adult Skin Fibroblasts
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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Area of Science:

  • Dermatology and Epigenetics
  • Drug Discovery and Development

Background:

  • Epigenetic modifications play a crucial role in skin health and regeneration.
  • Innovative therapeutic strategies are needed for preventive and regenerative skin care.

Purpose of the Study:

  • To explore the potential of epigenetic targets for novel drug development in skin health.
  • To review current preclinical and clinical advancements in epigenetic-based skin regeneration.

Main Methods:

  • Review of current literature on epigenetic targets in skin regeneration.
  • Analysis of ongoing clinical and preclinical trials for epigenetic-based small molecules.

Main Results:

  • Identified key epigenetic regions (VEGF, EGFR, TGFβ, DNMTs, HDAC1/2, miRNA) as druggable targets.
  • Highlighted a series of epigenetic-based small molecules in various stages of clinical and preclinical trials.

Conclusions:

  • Epigenetic targets represent a promising new platform for preventive and regenerative skin care.
  • Epigenetic writers, eraser targets, and readers are key therapeutic windows for future skin regeneration strategies.