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Related Experiment Videos

Regional hyperthermia: a feasibility analysis.

M V Pilepich1, R J Myerson, B N Emami

  • 1Washington University School of Medicine, Division of Radiation Oncology, St Louis, Missouri 63110.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|July 1, 1987
PubMed
Summary
This summary is machine-generated.

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Regional hyperthermia using the annular phased array system (APAS) with radiotherapy or chemotherapy was explored. Patient tolerance, primarily local discomfort, limited achieving target temperatures and durations, impacting treatment efficacy.

Area of Science:

  • Oncology
  • Medical Physics
  • Biomedical Engineering

Background:

  • Regional hyperthermia is an adjunct cancer treatment.
  • The annular phased array system (APAS) is used for hyperthermia delivery.
  • Optimizing hyperthermia efficacy requires understanding treatment limitations.

Purpose of the Study:

  • To analyze the feasibility and limitations of regional hyperthermia using APAS.
  • To evaluate treatment parameters and patient tolerance during hyperthermia sessions.
  • To identify factors affecting the achievement of therapeutic temperatures and durations.

Main Methods:

  • Thirty patients undergoing concurrent radiotherapy or chemotherapy received regional hyperthermia via APAS.
  • A total of 139 treatment sessions were analyzed.

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  • Data collected included hyperthermia sessions per patient, duration, achieved temperatures, and limiting factors.

    • Main Results:

    • The median number of hyperthermia sessions per patient was 4.6.
    • Therapeutic temperatures (≥42°C) were achieved in 68.8% of sessions, but for a median duration of only 8.5 minutes.
    • Local discomfort was the predominant limiting factor in 60% of patients, followed by generalized discomfort, systemic temperature elevation, and tachycardia.

    Conclusions:

    • Achieving target temperatures and durations for regional hyperthermia with APAS is challenging due to patient tolerance.
    • Local discomfort is a major limitation, suggesting a need for improved patient management and technical adjustments.
    • Optimizing technical details and patient preparation is crucial for enhancing heat delivery and treatment efficacy.