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Quantitative CT parameters correlate with lung function in chronic obstructive pulmonary disease: A systematic review
Yan Wang1, Limin Chai1, Yuqian Chen1
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Frontiers in Surgery
|January 23, 2023
Summary
Quantitative computed tomography (CT) parameters significantly correlate with airflow obstruction in chronic obstructive pulmonary disease (COPD) patients. CT imaging offers a valuable tool for assessing COPD, complementing pulmonary function tests and aiding in therapy development.
Area of Science:
- Pulmonary Medicine
- Radiology
- Medical Imaging Analysis
Background:
- Chronic obstructive pulmonary disease (COPD) is a major global health concern characterized by airflow limitation.
- Quantitative computed tomography (CT) provides detailed morphological information of the lungs.
- The correlation between CT-derived parameters and lung function in COPD requires comprehensive analysis.
Purpose of the Study:
- To systematically analyze the correlation between quantitative CT parameters and airflow obstruction in COPD patients.
- To evaluate the utility of CT imaging in assessing COPD severity and progression.
Main Methods:
- A systematic literature search was conducted across PubMed, Embase, Cochrane, and Web of Knowledge up to July 2022.
- Data from 64 eligible studies (6,341 participants) were meta-analyzed, extracting CT measurements (e.g., air trapping, airway wall thickness) and airflow obstruction parameters (e.g., FEV1%pred).
- Correlation coefficients were calculated, and heterogeneity was assessed.
Main Results:
- A significant correlation was found between quantitative CT parameters and lung function in COPD patients.
- Pooled correlation coefficients for inspiratory CT ranged from 0.26 to 0.70.
- Pooled correlation coefficients for expiratory CT ranged from 0.56 to 0.74.
Conclusions:
- Quantitative CT parameters are significantly associated with lung function in COPD.
- CT imaging allows for the evaluation of lung morphology beyond the capabilities of traditional pulmonary function tests.
- CT offers a quantitative approach to advance the development and testing of novel COPD interventions and therapies.
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