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Association of Angiotensin II Type 1 Receptor (AT1R) Gene Polymorphism with Angiotensin II Serum Levels in Patients

M Prasad1, D Rajarajeswari1, K Ramlingam1

  • 1Department of Biochemistry, Narayana Medical College and Hospital, Chinthareddy Palem, Nellore, Andhra Pradesh 524003 India.

Indian Journal of Clinical Biochemistry : IJCB
|January 23, 2023
PubMed

Insights

Essential hypertension (EH) risk is linked to the AT1R gene

Area of Science:

  • Cardiovascular Genetics
  • Molecular Medicine
  • Hypertension Research

Background:

  • Essential hypertension (EH) is a complex, polygenic condition with significant morbidity and mortality.
  • EH contributes to severe comorbidities like stroke, myocardial infarction, cardiac, and renal failure.
  • There is a need for population-based studies to understand EH pathophysiology and improve diagnosis and treatment.

Purpose of the Study:

  • To investigate the genotype and allele frequencies of the AT1R gene A1166C polymorphism in Indian patients with EH.
  • To correlate these genetic variations with serum Angiotensin II levels in hypertensive individuals.
  • To assess the association between AT1R gene polymorphism and the risk of developing essential hypertension in the Indian population.

Main Methods:

  • A case-control study involving 200 Indian patients with EH and 200 age- and gender-matched controls.
  • Genotyping of the AT1R gene A1166C polymorphism was performed.
  • Serum Angiotensin II levels were measured and correlated with genotypes.

Main Results:

  • The C/A heterozygote and allele C of the AT1R gene A1166C polymorphism were significantly associated with an increased risk of EH in both men and women.
  • Patients with EH exhibited higher serum Angiotensin II levels, particularly those with C/A and AA genotypes.
  • A significant association was found between the 1166 C/A polymorphism of the AT1R gene and an elevated risk of hypertension in the Indian population.

Conclusions:

  • The 1166 C/A polymorphism in the AT1R gene is a significant genetic risk factor for essential hypertension in the Indian population.
  • This polymorphism is associated with elevated serum Angiotensin II levels, suggesting a mechanistic link to hypertension.
  • These findings contribute to understanding the genetic underpinnings of EH and may inform future diagnostic or therapeutic strategies.

Keywords:
1166 C/A single nucleotide polymorphismAngiotensin IIEssential hypertensionGenetic associationPCR–RFLP

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