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Related Concept Videos

Brain Imaging01:14

Brain Imaging

275
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
275

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Related Experiment Video

Updated: Aug 13, 2025

A MRI-Based Toolbox for Neurosurgical Planning in Nonhuman Primates
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A multimodal imaging-guided software for access to primate brains.

Ehsan Rezayat1,2, Hamed Heidari-Gorji2,3, Pouya Narimani4

  • 1Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran.

Heliyon
|January 23, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces an open-source software tool for automated brain access using multiple imaging modalities. The software aids in precise neurosurgical planning for research and clinical applications, including drug delivery and biopsies.

Keywords:
Co-registrationElectrophysiologyImage-guided softwareRe-slicing

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Software Development

Background:

  • Imaging-guided brain access is crucial for research and clinical tasks like drug administration and tissue sampling.
  • Existing methods require specialized software for handling complex imaging datasets.

Purpose of the Study:

  • To develop and validate an open-source software tool for automating brain access procedures.
  • To facilitate precise calculation of target coordinates for minimally invasive interventions.

Main Methods:

  • The software co-registers multiple imaging modalities (e.g., MRI, CT) to provide detailed structural information.
  • It enables re-slicing of images to calculate brain region coordinates relative to entry points.
  • Atlas-based image segmentation is integrated for enhanced accuracy.

Main Results:

  • The software was successfully applied to electrophysiological recording in nonhuman primate brains with submillimeter resolution.
  • Drug infusion in nonhuman primate brains and guided biopsy in human subjects were validated.
  • Performance was comparable to commercial software in human biopsy procedures.

Conclusions:

  • The developed open-source software offers a versatile solution for imaging-guided brain access.
  • It precisely estimates target regions for implants and stereotactic frames, accommodating various materials.