Epidermal barrier function in patients after allogeneic hematopoietic stem cell transplantation - a pilot study

Area of Science:

• Dermatology
• Hematology
• Immunology

Background:

• The skin is frequently affected after allogeneic hematopoietic stem cell transplantation (alloHSCT).
• Supportive care for alloHSCT patients includes UV protection and emollients.
• Limited research exists on epidermal barrier function post-alloHSCT.

Purpose of the Study:

• To dermatologically monitor patients one year after alloHSCT, focusing on epidermal barrier function.
• To evaluate epidermal barrier properties in patients with chronic graft-versus-host disease (cGvHD).

Main Methods:

• A pilot study included 30 alloHSCT patients (10 monitored longitudinally, 20 with cGvHD) and 20 healthy controls.
• Evaluated transepidermal water loss (TEWL), skin hydration, and skin color using noninvasive methods.
• Clinical assessments and noninvasive evaluations were performed at various time points post-alloHSCT or once for cGvHD patients.

Main Results:

• No significant changes in TEWL, corneometry, erythema, or melanin were found in the longitudinal monitoring group.
• Patients with sclerodermoid cGvHD showed the highest TEWL and lowest corneometry results.
• TEWL and melanin levels were significantly higher in cGvHD patients compared to controls.

Conclusions:

• This study provides initial evidence of disturbed epidermal barrier function in patients post-alloHSCT.
• Appropriate skin care, including photoprotection, is essential for long-term management of these patients.