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Related Experiment Video

Updated: Aug 13, 2025

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Aptamer-based rapid diagnosis for point-of-care application.

Abhishek Futane1, Vigneswaran Narayanamurthy2,3, Pramod Jadhav4,5

  • 1Fakulti Kejuruteraan Elektronik Dan Kejuruteraan Komputer, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, Durian Tunggal, 76100 Melaka, Malaysia.

Microfluidics and Nanofluidics
|January 23, 2023
PubMed
Summary
This summary is machine-generated.

Aptasensors offer rapid, accurate point-of-care testing (POCT) for diseases. This review details aptasensor design and virus detection strategies for faster diagnostics and treatment.

Keywords:
AptamerBiosensorsDiagnosisPoint of care

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Molecular Diagnostics

Background:

  • Point-of-care testing (POCT) aims to reduce diagnostic and treatment times compared to centralized facilities.
  • Aptamer-based biosensors offer advantages over traditional antibody or enzyme-based sensors for disease detection.
  • The need for rapid, accessible diagnostics is critical, especially during epidemics.

Purpose of the Study:

  • To review design strategies and virus detection methods using aptamer-based sensors.
  • To discuss the principles and importance of aptamers in biosensing.
  • To highlight the advantages of aptasensors for point-of-care (POC) applications.

Main Methods:

  • Comprehensive literature review of aptasensor design and applications.
  • Analysis of aptamer selection and detection principles.
  • Classification of POC aptasensor diagnostic applications for infectious and non-infectious diseases.

Main Results:

  • Aptasensors provide sensitive, specific, and flexible detection methods for rapid diagnostics.
  • POC aptasensors are crucial for early disease detection, epidemic control, and reducing healthcare burdens.
  • Various design factors are outlined for developing future rapid POC aptasensors.

Conclusions:

  • Aptasensors are highly promising for advancing point-of-care diagnostics.
  • Further development of aptasensor technology will enhance disease management and public health.
  • Optimized aptasensor designs are key to meeting the demand for fast, reliable POC testing.