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Published on: June 11, 2012
Impact of Advanced Hybrid Closed Loop on Youth With High-Risk Type 1 Diabetes Using Multiple Daily Injections
Alisa Boucsein1, Antony S Watson2, Carla M Frewen1
11Department of Women's and Children's Health, University of Otago, Dunedin, New Zealand.
Objective:
To evaluate glycemic outcomes in youth (aged 13-25 years) with type 1 diabetes and high-risk glycemic control (HbA1c ≥8.5% [69 mmol/mol]) on multiple daily injection (MDI) therapy after transitioning to advanced hybrid closed loop (AHCL) therapy.
Research Design And Methods:
This prospective, 3-month, single-arm, dual-center study enrolled 20 participants, and all completed the study.
Results:
HbA1c decreased from 10.5 ± 2.1% (91.2 ± 22.8 mmol/mol) at baseline to 7.6 ± 1.1% (59.7 ± 11.9 mmol/mol), and time spent in target range 70-180 mg/dL (3.9-10.0 mmol/L) increased from 27.6 ± 13.2% at baseline to 66.5 ± 9.8% after 3 months of AHCL. Two episodes of diabetic ketoacidosis attributed to infusion set failure occurred.
Conclusions:
AHCL has the potential to improve suboptimal glycemia in youth with type 1 diabetes previously on MDI therapy.
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