Racial Disparity Between the Post-Procedural Outcomes Among Patients With Peripheral Artery Disease: A Systematic...

Area of Science:

• Vascular Surgery
• Health Disparities
• Cardiovascular Outcomes

Background:

• Racial disparities in clinical outcomes after Peripheral Artery Disease (PAD) interventions are understudied.
• Limited literature exists on post-procedure outcomes comparing Black and White PAD patients.

Purpose of the Study:

• To conduct a meta-analysis evaluating post-procedure outcomes in PAD patients, comparing Black and White racial groups.
• To identify significant differences in major amputation, myocardial infarction, and mortality rates between these groups.

Main Methods:

• Systematic search of electronic databases until November 2022.
• Meta-analysis of 136,395 PAD patients (19,218 Black, 117,177 White).
• Primary endpoint: major amputation within 30 days. Secondary endpoints: myocardial infarction (MI), 30-day mortality, and all-cause mortality (ACM).

Main Results:

• Black patients had a significantly higher odds of major amputation within 30 days (OR, 0.40; P=0.02).
• White patients showed higher odds of MI within 30 days (OR, 1.29; P<0.02).
• No significant differences were found in ACM (OR, 0.97; P=0.88) or 30-day mortality (OR, 1.09; P=0.64).

Conclusions:

• Black PAD patients face a higher risk of major amputation within 30 days post-intervention compared to White patients.
• Mortality rates were comparable between Black and White PAD patients.
• This study represents the largest meta-analysis to date on racial disparities in PAD intervention outcomes.