Related Experiment Video

Updated: Aug 13, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

18.6K

Effect of maternal immunisation with multivalent vaccines containing inactivated poliovirus vaccine (IPV) on infant

Nicholas C Grassly1, Nick Andrews2, Gillian Cooper3

  • 1MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, UK.

Vaccine
|January 23, 2023
PubMed

Insights

Maternal immunization with diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) in the UK may reduce infant protection against polio. Infants born to vaccinated mothers showed lower antibody responses to inactivated poliovirus vaccine (IPV).

Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Background:

  • The UK introduced maternal immunization with diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) in 2012.
  • Maternal vaccination aims to protect infants from vaccine-preventable diseases during their first months of life.

Purpose of the Study:

  • To evaluate the impact of maternal DTaP/IPV immunization on the infant immune response to inactivated poliovirus vaccine (IPV).
  • To assess poliovirus-specific neutralizing antibodies in infants at 2, 5, and 13 months of age.

Main Methods:

  • A randomized, phase 4 study compared infants born to mothers receiving DTaP/IPV during pregnancy versus a non-randomized group whose mothers did not receive the vaccine.
  • Poliovirus-specific neutralizing antibodies were measured at 2, 5, and 13 months of age.

Main Results:

  • Infants born to mothers who received DTaP/IPV showed significantly lower seroconversion rates after three IPV doses compared to infants of unvaccinated mothers.
  • At 13 months, seropositivity for poliovirus types 1-3 was lower in the DTaP/IPV maternal immunization group (57.2%, 42.6%, 37.0%) compared to the control group (90.9%, 90.9%, 70.0%).

Conclusions:

  • Maternal DTaP/IPV immunization in the UK may lead to suboptimal protection against poliomyelitis in infants until their pre-school booster vaccination.
  • Further research is needed to optimize infant immunization schedules in the context of widespread maternal vaccination programs.

Keywords:
Immunization policyMaternal immunisationPoliomyelitisPoliovirus vaccinesVaccination schedule

More Related Videos

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.8K
Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.7K

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
407
Vaccinations01:51

Vaccinations

Overview
45.1K
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
2.6K
Active versus Passive Immunity01:31

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
2.2K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
863