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Updated: Aug 13, 2025

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Vesicle-Associated Actin Assembly by Formins Promotes TGFβ-Induced ANGPTL4 Trafficking, Secretion and Cell Invasion

Dennis Frank1, Christel Jessica Moussi1,2, Svenja Ulferts1

  • 1Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Freiburg, 79104, Freiburg, Germany.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 24, 2023
PubMed
Summary

Formin-like 2 (FMNL2) controls cancer cell invasion by regulating Angiopoietin-like 4 (ANGPTL4) secretion. This protein is essential for ANGPTL4 vesicle trafficking and actin polymerization, impacting tumor progression.

Keywords:
TGFβ−signalingactin dynamicsforminsinvasionvesicle trafficking

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