Mannose: a potential saccharide candidate in disease management

Area of Science:

• Nutraceuticals and Drug Discovery
• Carbohydrate Chemistry
• Infectious Disease Therapeutics

Background:

• Antibiotic resistance and emerging infectious diseases pose significant global health threats.
• Pathogen evolution necessitates novel therapeutic strategies beyond traditional antibiotics.
• Drug repurposing and artificial intelligence accelerate the discovery of new treatments.

Purpose of the Study:

• To review the multifaceted roles of D-Mannose in disease management.
• To explore D-Mannose's potential as a nutraceutical and drug delivery enhancer.
• To identify targetable proteins associated with D-Mannose in pathogens and humans.

Main Methods:

• Data mining from the ChEMBL database.
• Analysis of D-Mannose's protein targets.
• Review of existing literature on D-Mannose's therapeutic applications.

Main Results:

• D-Mannose exhibits potential against Congenital Disorders of Glycosylation (CDG), diabetes, obesity, lung disease, and autoimmune diseases.
• Recent findings indicate anti-tumor activity and utility in drug delivery enhancement.
• Analysis identified 50 targetable proteins for D-Mannose, with a majority on human cells.

Conclusions:

• D-Mannose is a promising natural molecule with broad therapeutic potential.
• Understanding its targets is crucial for developing effective disease management strategies.
• D-Mannose represents a hopeful avenue for future drug discovery and development.