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Updated: Aug 12, 2025

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Definition of the term asymmetric synthesis-History and revision
1Organisch-Chemisches Institut, Universität Heidelberg, Heidelberg, Germany.
Abstract:
The widely used term asymmetric synthesis was introduced by Emil Fischer in 1894 by demonstration with examples. An early definition by Marckwald was successful in applications involving enantiomeric reaction products. The term caused difficulties in cases of diastereomeric products, because of a lack of a clear definition of the term diastereoisomers, which in turn affected the introduction of the term diastereoselectivity. Clarity was reached only after Wheland had revived a definition by Victor Meyer of 1907. Today, a definition codified by the International Union of Pure and Applied Chemistry (IUPAC) is in use, which is slightly modified here.
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