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Related Concept Videos

Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

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Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
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Formation of Dilute Urine01:20

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The formation of dilute urine is a critical renal adaptation that maintains fluid balance, particularly during periods of high fluid intake. This process primarily involves the juxtamedullary nephrons. By adjusting the permeability of water and ions in response to physiological conditions, the kidneys can either conserve or excrete water, resulting in concentrated or dilute urine.
Filtrate Osmolarity in the PCT
Initially, as the filtrate passes through the proximal convoluted tubule (PCT), its...
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Related Experiment Video

Updated: Aug 12, 2025

Generation and Maintenance of Primate Induced Pluripotent Stem Cells Derived from Urine
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Generation and Maintenance of Primate Induced Pluripotent Stem Cells Derived from Urine

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Live births from urine derived cells.

P Olof Olsson1, Jeong Yeonwoo2, Kyumi Park3

  • 1Fujairah Genetics Center, Fujairah, UAE.

Plos One
|January 25, 2023
PubMed
Summary

Urine-derived cells (UDCs) offer a noninvasive method for cloning animals, yielding healthy cloned canine pups. This breakthrough provides a new way to preserve the breeding potential of valuable animals.

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Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Animal Science

Background:

  • Traditional cell sources for cloning can be invasive.
  • Urine represents an accessible and non-invasive source of cellular material.
  • Previous research has not fully explored the potential of urine-derived cells (UDCs) for reproductive applications.

Purpose of the Study:

  • To investigate the feasibility of using urine-derived cells (UDCs) for animal cloning.
  • To assess the viability and characteristics of UDCs.
  • To compare the developmental potential of UDC-derived embryos with other methods.

Main Methods:

  • Culture and cryopreservation of bovine and canine UDCs.
  • Analysis of UDC viability and membrane integrity after storage in urine.
  • Transfection of UDCs with plasmids.
  • Embryo development assessment using TUNEL staining.
  • Somatic cell nuclear transfer (SCNT) using UDCs in canines.

Main Results:

  • UDCs remained viable and culturable after 48 hours in urine.
  • UDCs demonstrated multipotent lineage potential.
  • UDC-derived embryos showed no significant differences in cell number or DNA breaks compared to IVF or traditional SCNT embryos.
  • Canine cloning using UDCs resulted in a 25% pregnancy rate and two healthy live births.

Conclusions:

  • UDCs are a viable cell source for producing live offspring via SCNT.
  • This noninvasive method offers a promising approach for preserving the reproductive capacity of genetically important or infertile animals.
  • UDCs can serve as valuable cellular material for both animal and human research.