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Related Concept Videos

Caspases01:24

Caspases

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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection
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CaspSites: A Database and Web Application for Experimentally Observed Human Caspase Substrates Using N-Terminomics.

Henry Wang1, Olivier Julien1

  • 1Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G2H7, Canada.

Journal of Proteome Research
|January 25, 2023
PubMed
Summary

CaspSites is a new database detailing human caspase cleavage sites found through N-terminomics. This resource aids researchers in understanding caspase roles in cellular processes by identifying target proteins.

Keywords:
N-terminomicsapoptosiscaspase substratesdatabaseweb application

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Human caspases are crucial proteases involved in apoptosis and other cellular processes.
  • Identifying their substrates and cleavage sites is essential for understanding their functions.
  • Existing resources may not comprehensively cover experimentally validated caspase-substrate interactions.

Purpose of the Study:

  • To develop and present CaspSites, a comprehensive, free-to-use database of experimentally observed human caspase substrates.
  • To provide a web application for querying, viewing, and exporting caspase cleavage site information.
  • To facilitate research into the specific roles of human caspases in cellular functions.

Main Methods:

  • Utilized N-terminomics techniques to identify caspase cleavage sites.
  • Collected and curated data from published studies on human caspases 1-9.
  • Developed a web application with advanced search functionalities (protein substrate, cleavage site, caspase data sets) using logical operators (OR, AND, NOT).

Main Results:

  • Established CaspSites, a database containing experimentally verified human caspase cleavage site information.
  • The web application allows for flexible, custom queries based on various parameters.
  • The database includes data for human caspases 1-9 from both lysates and apoptotic cells.

Conclusions:

  • CaspSites provides a valuable, accessible resource for researchers studying human caspases.
  • The database will be regularly updated to include new findings, especially for understudied caspases.
  • This resource will enhance insights into the distinct roles of human caspases by mapping their target proteins.