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Updated: Aug 12, 2025

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
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CircCCDC66: Emerging roles and potential clinical values in malignant tumors

Xiaoxiao Wang1, Chao Zhang1, Huangqin Song1

  • 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.

Frontiers in Oncology
|January 26, 2023
PubMed

Insights

Circular RNAs (circRNAs) are novel oncogenic molecules found in many cancers. CircCCDC66 shows potential as a biomarker for cancer diagnosis, prognosis, and targeted therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • RNA Biology

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs with a unique closed-loop structure.
  • CircCCDC66 is identified as an oncogenic circRNA upregulated in various cancers.
  • Its role in cancer progression via epigenetic modifications, splicing, transcription, and translation is increasingly recognized.

Purpose of the Study:

  • To review the expression, biological functions, and regulatory mechanisms of circCCDC66 in malignant and non-tumor diseases.
  • To evaluate the clinical value and prognostic significance of circCCDC66.
  • To provide insights for developing new strategies for early cancer diagnosis and targeted treatment.

Main Methods:

  • Literature review and synthesis of existing research on circCCDC66.
  • Analysis of circCCDC66 expression patterns in various cancers.
  • Evaluation of circCCDC66's functional roles and regulatory pathways in tumorigenesis.

Main Results:

  • CircCCDC66 is upregulated in multiple cancers, including thyroid, gastric, and colorectal cancers.
  • It influences cancer progression by modulating epigenetic modifications, splicing, transcription, and translation.
  • CircCCDC66 acts as an oncogene, suppressing or promoting gene expression through direct/indirect pathways.

Conclusions:

  • CircCCDC66 holds significant potential as a biomarker for cancer diagnosis, prognosis assessment, and treatment.
  • Understanding circCCDC66's mechanisms offers new avenues for early cancer detection and targeted therapies.
  • Further research into circCCDC66 is crucial for advancing oncology strategies.
Keywords:
cancer progressioncircCCDC66circular RNAendogenous competitive RNAmalignant tumorsregulatory mechanism

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