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Ca2+ releasing effect of perezone on adrenal cortex mitochondria
A Cuéllar1, A Cárabez, E Chávez
1Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez, México, D.F.
Life Sciences
|October 26, 1987
Abstract:
Ca2+ energy-coupled transport was analized in adrenal cortex mitochondria using the sesquiterpenic drug perezone. Perezone promotes Ca2+ efflux by inducing collapse of the membrane potential and oxidation of pyridine nucleotides. The effect of perezone on mitochondrial Ca2+ release follows a dose-response relationship and is dependent of the reduction of the drug. These data suggest that perezone may produce a cytotoxic effect through an impairment in Ca2+ homeostasis.