Related Experiment Video
Updated: Aug 12, 2025
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Repeatability of corneal deformation response parameters by dynamic ultra-high-speed Scheimpflug imaging before and
Robert Herber1, Riccardo Vinciguerra, Costanza Tredici
1From the Department of Ophthalmology, Univ. Hospital Carl Gustav Carus, TU Dresden, Germany (Herber, Pillunat, Raiskup); Humanitas San Pio X Hospital, Milan, Italy (R. Vinciguerra); IRCCS Humanitas Research Hospital, Milan, Italy (Tredici, Legrottaglie, P. Vinciguerra); Department of Biomedical Sciences, Humanitas University, Milan, Italy (P. Vinciguerra).
Purpose:
To evaluate the repeatability of deformation corneal response (DCR) parameters before and after corneal crosslinking (CXL) compared with their untreated fellow eyes (uFEs).
Setting:
University Hospital Carl Gustav Carus, Dresden, Germany; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Design:
Multicenter, interventional reliability analysis.
Methods:
53 eyes of 53 patients with keratoconus who received CXL treatment after the disease progression (CXL group) were included. Patients were measured 3 times using a dynamic Scheimpflug analyzer to determine repeatability before and 1 month after CXL treatment. The uFEs were measured in the same way (uFE group). Reliability of DCR parameters was assessed by a coefficient of repeatability, coefficient of variation, and intraclass correlation coefficient (ICC).
Results:
The repeatability of DCR parameters did not change after CXL compared with the preoperative values for all investigated DCR parameters ( P > .05). In the uFE group, no statistically significant shift was observed regarding the repeatability ( P > .05). An ICC greater than 0.75 was achieved in both groups for almost all parameters. Concerning the biomechanical stiffening induced by CXL, integrated inverse radius and stress-strain index were found to be statistically significantly decreased and increased ( P < .001), respectively, both indicating stiffening. No changes were observed for the uFE group.
Conclusions:
The study demonstrated highly repeatable measurements of the dynamic Scheimpflug analyzer before and after CXL. The improvement of certain DCR parameters after CXL confirmed the capability of the device to detect the stiffening effect.
More Related Videos
12:25Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
Published on: January 6, 2018
07:51Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022