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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Updated: Aug 12, 2025

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

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Targeted Lymphoma Therapy Using a Gold Nanoframework-Based Drug Delivery System.

Manpreet Bariana¹, Beilu Zhang², Jingyu Sun²

¹Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States.

ACS Applied Materials & Interfaces

|January 26, 2023

Summary

A novel hyaluronic acid-coated gold nanoframework (HA-AuNF) effectively delivers the anti-cancer drug IT848 to lymphoma and myeloma cells. This nanomedicine approach enhances drug efficacy and safety for targeted cancer therapy.

Keywords:

CD44 gold nanoparticles hyaluronic acid lymphoma nuclear factor-κB inhibitor targeted drug delivery

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Area of Science:

Nanomedicine
Biotechnology
Materials Science

Background:

Traditional cancer therapies like chemotherapy and radiotherapy have limitations, including a narrow therapeutic window and off-target side effects.
Targeting nuclear factor kappa B (NF-κB) offers a promising strategy for treating lymphoma and myeloma.
Developing advanced drug delivery systems is crucial for improving cancer treatment efficacy and safety.

Purpose of the Study:

To formulate and characterize a novel nanotherapeutic system for targeted delivery of IT848.
To evaluate the efficacy and safety of the developed nanomedicine in preclinical models of lymphoma and myeloma.
To explore the potential of hyaluronic acid-coated gold nanoframeworks (HA-AuNFs) as a platform for precision cancer therapy.

Main Methods:

Fabrication of porous gold nanoframeworks (AuNFs) using a liposome-templated approach.
Encapsulation of IT848 within AuNFs and surface functionalization with hyaluronic acid (HA).
In vitro evaluation of drug delivery specificity and efficacy in lymphoma and myeloma cell lines, and in vivo studies for biodistribution, pharmacokinetics, and therapeutic effectiveness in mouse models.

Main Results:

The HA-AuNF system efficiently delivered IT848 with high specificity to lymphoma and myeloma cells in vitro.
In vivo studies demonstrated favorable biodistribution, pharmacokinetics, and safety profiles of HA-AuNFs.
HA-AuNF-formulated IT848 showed superior efficacy compared to free IT848 in lymphoma mouse models, with enhanced therapeutic effects at minimal doses.

Conclusions:

The developed HA-AuNF nanocomposite is a potent nanomedicine platform for targeted delivery of IT848.
This approach significantly improves the drug's safety profile and enhances its efficacy against lymphoma and myeloma.
The HA-AuNF-formulated IT848 holds strong potential for clinical translation in precision cancer therapy.