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Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
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Transcription networks rewire gene repertoire to coordinate cellular reprograming in prostate cancer

Nishat Manzar1, Promit Ganguly1, Umar Khalid Khan1

  • 1Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India.

Seminars in Cancer Biology
|January 26, 2023
PubMed

Insights

Transcription factors (TFs) are key regulators in cancer, particularly prostate cancer. Targeting these deregulated proteins and their cofactors offers new therapeutic strategies for disease progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Transcription factors (TFs) are frequently deregulated in human cancers.
  • TF dysregulation drives cellular reprogramming and cancer progression.
  • Prostate cancer development and maintenance are linked to TF deregulation.

Purpose of the Study:

  • To discuss the role of key TFs in prostate cancer development and progression.
  • To highlight TFs involved in cancer hallmarks like chromatin remodeling and metastasis.
  • To explore TF functions in lineage plasticity and neuroendocrine prostate cancer.

Main Methods:

  • Literature review and synthesis of current research on TFs in prostate cancer.
  • Analysis of TF roles in regulating transcriptional circuitries.
  • Discussion of TF involvement in cancer hallmarks and therapeutic targeting.

Main Results:

  • Specific TFs modulate transcriptional networks crucial for prostate cancer.
  • TFs are implicated in chromatin remodeling, genome instability, DNA repair, invasion, and metastasis.
  • TFs contribute to lineage plasticity, driving progression to neuroendocrine prostate cancer.

Conclusions:

  • TFs are central players in prostate cancer pathogenesis and progression.
  • Understanding TF functions provides insights into cancer hallmarks.
  • Therapeutic targeting of TFs and cofactors shows promise for clinical intervention.
Keywords:
Chromatin remodelingEpithelial-mesenchymal transitionLineage plasticityPioneer factorsTherapy resistance

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