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Pathological consequences of DNA damage in the kidney
Juan I Garaycoechea1, Catherine Quinlan2,3,4, Martijn S Luijsterburg5
1Hubrecht Institute-KNAW, University Medical Center Utrecht, Utrecht, The Netherlands. juan.g@hubrecht.eu.
Nature Reviews. Nephrology
|January 26, 2023
Summary
DNA damage in the kidney can cause mutations, cancer, and aging. Understanding the kidney
Area of Science:
- Nephrology
- Molecular Biology
- Genetics
Background:
- DNA damage is implicated in kidney injury, cancer, and aging.
- The kidney is susceptible to DNA-damaging chemotherapeutics.
- Links exist between kidney ciliopathies and DNA damage response.
Purpose of the Study:
- To explore the role and consequences of DNA damage in kidney cells.
- To understand cellular and systemic responses to kidney DNA damage.
- To investigate the link between DNA repair deficiencies and kidney disease.
Main Methods:
- Utilized genetic tools in mice.
- Employed kidney organoid models.
- Applied single-cell RNA sequencing technologies.
Main Results:
- Identified specific kidney cell type responses to DNA damage.
- Revealed DNA damage impacts the kidney microenvironment.
- Observed induction of cell proliferation and systemic responses to genotoxic stress.
Conclusions:
- DNA damage is critical to nephrotoxicity and kidney disease phenotypes.
- Cellular responses to DNA damage influence kidney health.
- Understanding DNA damage pathways is key for kidney disease treatment.
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