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Updated: Aug 12, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
['Wait and see' in paediatric epilepsy. Our experience]
B Salinas-Salvador1, A Moreno-Sánchez1, G Carmen-Marcén1
1HUMS. Hospital Universitario Miguel Servet, 50009 Zaragoza, España.
Insights
Pharmacological treatment for epilepsy in children should consider quality of life and neurodevelopment over seizure frequency alone. Decisions on antiepileptic drugs require parental agreement.
Area of Science:
- Pediatric Neurology
- Epileptology
Context:
- Epilepsy management in children often involves pharmacological treatment.
- Current treatments aim to control seizures but do not offer a cure.
- The decision to initiate treatment is complex and impacts a child's life.
Purpose:
- To analyze the outcomes of children with non-symptomatic seizures who did not receive pharmacological treatment.
- To evaluate the experience with untreated epilepsy in a pediatric neurology setting.
Summary:
- A study analyzed 65 children with non-symptomatic seizures, some experiencing single or multiple events.
- Electroencephalogram and neuroimaging findings varied, with a significant portion showing abnormalities.
- Follow-up periods averaged 2.7 to 3.8 years, observing seizure patterns and characteristics.
Impact:
- Treatment decisions for childhood epilepsy should prioritize quality of life and neurodevelopment.
- Parental involvement and agreement are crucial in managing antiepileptic drug therapy.
- This approach may lead to more individualized and less aggressive treatment strategies.
Introduction:
Pharmacological treatment of epilepsy is not healing; it tries to avoid seizures, as far as possible, in children who probably would still have them.
Patients And Methods:
Our purpose is to analyse our experience with epileptic children and those who have a first non-symptomatic seizure without pharmacological treatment. Patients seen in a paediatric neurology consultation, from 2017 to 2021, who had suffered one or more acute non-symptomatic crises and who had not been treated pharmacologically, were analysed.
Results:
Sixty-five patients meet the selection criteria. Twenty-four patients had had a single crisis with a mean duration of 12 minutes (1-60). In 66.7% it was nocturnal. 41.7% presented pathological electroencephalogram, and 21% pathological findings in neuroimaging. The mean control time was 2.7 years (0.003-13.6 years). Forty-one presented more than one crisis, with a mean duration of nine minutes (1-60). Five patients presented more than 20 seizures, the rest between two and 17. Twenty-four (58.5%) presented only nocturnal seizures. An electroencephalogram was performed in all: epileptiform graphoelements in 63.4%; and neuroimaging in all: pathological in 4.9%. Mean control time was 3.8 years (0.01-9.1 years).
Conclusions:
Seizure frequency, underlying pathology or test results should not be the only variables to take into consideration when starting antiepileptic drug treatment. The repercussion on their quality of life and neurodevelopment should prevail, agreeing on this decision with the parents.
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