Breast-Conserving Surgery in Triple-Negative Breast Cancer: A Retrospective Cohort Study.

Area of Science:

• Oncology
• Surgical Oncology
• Medical Oncology

Background:

• Triple-negative breast cancer (TNBC) presents unique treatment challenges.
• Neoadjuvant chemotherapy (NAC) is a standard treatment approach for TNBC.
• Breast-conserving surgery (BCS) is increasingly explored in combination with NAC.

Purpose of the Study:

• To evaluate the efficacy and prognosis of NAC combined with BCS in TNBC patients.
• To identify factors influencing NAC efficacy and patient outcomes.
• To analyze predictors of treatment response and survival in TNBC.

Main Methods:

• Retrospective cohort study comparing NAC+BCS versus NAC alone.
• Analysis of operation-related indicators, complications, recurrence, metastasis, and overall survival (OS).
• Logistic and Cox regression models used to identify influencing factors and predictors, with ROC curve analysis for optimal cutoff values.

Main Results:

• NAC+BCS demonstrated reduced blood loss, fewer complications, and shorter hospital stays compared to NAC alone.
• No significant differences in local recurrence, distant metastasis, or OS between the groups.
• High Ki-67 expression was an independent predictor of NAC efficacy, prognosis, and OS, with specific AUC values and cutoff points identified.

Conclusions:

• NAC combined with BCS is effective for TNBC, showing good short-term outcomes and prognosis.
• Clinical stage I and high Ki-67 expression are protective factors for NAC efficacy.
• Ki-67 expression levels are crucial predictors for NAC efficacy, prognosis, and OS in TNBC.