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No Increased Risk of Taking Additional Intestinal Mucosal Research Biopsies From the Duodenum During Pediatric

Tracey M DaFonte1,2,3, Elizabeth Gleeson2,3, Taylor Morson2,3

  • 1From the Division of Pediatric Gastroenterology, Department of Pediatrics, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA.

Journal of Pediatric Gastroenterology and Nutrition
|January 27, 2023
PubMed

Insights

Pediatric endoscopy is safe for obtaining duodenal research biopsies in children with celiac disease (CeD). Additional biopsies did not increase the risk of adverse events like pain or fever.

Area of Science:

  • Gastroenterology
  • Pediatric Endoscopy
  • Celiac Disease Research

Background:

  • Celiac disease (CeD) diagnosis necessitates duodenal biopsies, making intestinal tissue studies crucial.
  • Understanding CeD in pediatric populations requires specific research in children.

Purpose of the Study:

  • To evaluate the safety and risk associated with obtaining duodenal research biopsies during pediatric endoscopy.
  • To determine if additional biopsies increase adverse event rates in children undergoing endoscopy.

Main Methods:

  • Retrospective chart review of 1180 pediatric subjects and controls.
  • Data collected from 2016 to 2022.
  • Analysis of procedure-related adverse events within 48 hours post-endoscopy.

Main Results:

  • A total of 18 procedure-related adverse events were recorded within 48 hours.
  • The majority of adverse events reported were symptoms of pain and fever.
  • No statistically significant increase in adverse events was observed when additional duodenal research biopsies were obtained.

Conclusions:

  • Performing research biopsies during pediatric endoscopy is a safe procedure for children.
  • The number of duodenal research biopsies taken does not appear to elevate the risk of adverse events.
  • This supports the continued use of duodenal biopsies in pediatric celiac disease research.

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