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Evaluation of Chronic Constipation in Children With Autism Spectrum Disorder
Alexander Coe1, Jacob Ciricillo2, Sherief Mansi3
1From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Journal of Pediatric Gastroenterology and Nutrition
|January 27, 2023
Summary
Children with autism spectrum disorder (ASD) do not have more abnormal colonic motility with chronic constipation. However, constipation duration and soiling can help identify ASD children at higher risk for motility issues.
Area of Science:
- Pediatric Gastroenterology
- Neurodevelopmental Disorders
- Gastrointestinal Motility
Background:
- Chronic constipation is prevalent in children with autism spectrum disorder (ASD).
- Understanding the underlying mechanisms, such as colonic motor activity, is crucial for effective management.
- Abnormal colonic motility may contribute to constipation in this population.
Purpose of the Study:
- To compare the rate of abnormal colonic motor activity in children with ASD and chronic constipation versus non-ASD children.
- To identify clinical variables that predict abnormal colonic motility in children with ASD.
Main Methods:
- A retrospective, propensity-matched, case-control study.
- Colonic manometry (CM) was used to assess colonic motor activity.
- Clinical variables were analyzed for predictive value.
Main Results:
- No significant difference in abnormal CM findings between ASD (24%) and non-ASD (20%) children.
- A prediction model including ASD diagnosis, constipation duration, and soiling showed high sensitivity (0.94) and specificity (0.65).
- Constipation duration (11% increased risk per year) and soiling (30x higher odds in ASD children) were significant predictors.
Conclusions:
- Chronic constipation in children with ASD is not associated with a higher prevalence of abnormal colonic motor activity.
- Disease duration and the presence of soiling are promising clinical indicators for identifying ASD children at increased risk for abnormal colonic motility.
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