Hormone-linked redox status and its modulation by antioxidants
Dipak Kumar Sahoo1, Gagan B N Chainy2
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa States University, Ames, IA, United States.
Vitamins and Hormones
|January 27, 2023
Summary
Hormones significantly influence the body's redox status, impacting life's dynamics from development to aging. Understanding hormone-antioxidant interactions offers new therapeutic strategies for hormonal disorders.
Area of Science:
- Endocrinology and Redox Biology
- Explores the intricate relationship between hormonal regulation and cellular redox balance.
Background:
- Hormonal disruptions are a key cause of oxidative stress in vertebrates.
- The interplay between hormones, redox state, and oxidative stress is complex, with some hormones acting as oxidants and others as antioxidants.
Purpose of the Study:
- To discuss the beneficial impacts of antioxidant hormones and protective effects of various antioxidants against hormone-induced oxidative stress.
- To highlight the challenges in correlating hormonal changes with redox status and oxidative stress across different life stages and sexes.
Main Methods:
- Literature review and discussion of existing research on hormone-redox interactions.
- Analysis of the roles of specific hormones (e.g., melatonin, insulin, estrogens) and antioxidants (e.g., vitamins, curcumin, resveratrol) in managing oxidative stress.
Main Results:
- Identifies hormones like melatonin, glucagon, insulin, estrogens, and progesterone as having antioxidative properties.
- Details the protective effects of antioxidants against oxidative stress induced by hormones like aldosterone, glucocorticoids, and catecholamines.
Conclusions:
- Understanding the synergistic action of antioxidants and hormones is crucial for maintaining cellular redox status.
- Identifying hormonal changes and antioxidant actions can lead to novel therapeutic strategies for hormonal imbalance-related disorders and aging.
Keywords:
Antioxidant defense systemAntioxidantsHormonesOxidative stressReactive oxygen speciesRedox statusMore Related Videos
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