Biosensor integrated brain-on-a-chip platforms: Progress and prospects in clinical translation
Berivan Cecen1, Ecem Saygili2, Iman Zare3
1Department of Mechanical Engineering, Rowan University, Glassboro, NJ, 08028, USA; Department of Biomedical Engineering, Rowan University, Glassboro, NJ, 08028, USA.
Biosensors & Bioelectronics
|January 29, 2023
Summary
Brain-on-a-chip (BoC) technology simulates the central nervous system (CNS) in vitro, offering advanced models for neurological disorder research. Defining key parameters enhances these platforms for better brain microenvironment replication and clinical translation.
Area of Science:
- Neuroscience
- Biotechnology
- Medical Engineering
Background:
- Neurological disorder treatment development is challenging due to brain complexity.
- In vitro systems, particularly brain-on-a-chip (BoC) technology, are advancing to mimic brain structure and function.
- BoC has evolved from simulating small tissues to in vitro central nervous system (CNS) simulation.
Approach:
- Defining qualifying parameters for BoC systems is crucial for next-generation in vitro platforms.
- These parameters assess the platform's ability to replicate the brain's microenvironment and include components like the blood-brain barrier (BBB).
- The review covers practical concerns in creating and deploying BoC systems and their potential applications.
Key Points:
- Integration of advanced biosensing technologies with BoC systems.
- Novel approaches for assay automation and point-of-care (PoC) diagnostics.
- Accurate quantitative analyses and overcoming challenges for clinical translation in neurodegenerative disorders.
Conclusions:
- BoC technology offers significant value over traditional cell culture for in vitro CNS modeling.
- Further development and parameter definition will enhance BoC capabilities for neurological research.
- Addressing key challenges is essential for the clinical translation of BoC in neurodegenerative diseases.
