Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Catenins01:23

Catenins

2.4K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.4K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

2.7K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
2.7K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
Microtubules in Signaling01:22

Microtubules in Signaling

1.8K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.8K
Physiology of Respiration II: Neurogenic Control of Respiration01:22

Physiology of Respiration II: Neurogenic Control of Respiration

744
The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
744
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microplastic Pollution in Agricultural Waters in the Mississippi Delta.

Journal of xenobiotics·2026
Same author

Characterizing Airborne Particulate Matter During Late-Season Soybean Production Using SEM/EDX Automated Single Particle Analyses and Machine Learning: A Preliminary Study in the Mississippi Delta.

Bulletin of environmental contamination and toxicology·2026
Same author

Barking up the right tree: ecological insights into the microbiome of bald cypress tree bark.

Environmental microbiome·2026
Same author

Field Evaluation of Rice Husk Biochar and Pine Tree Woodchips for Removal of Tire Wear Particles from Urban Stormwater Runoff in Oxford, Mississippi (USA).

Sustainability·2026
Same author

A spinal circuit for skilled locomotion.

Current biology : CB·2025
Same author

A cholinergic spinal pathway for the adaptive control of breathing.

Cell reports·2025

Related Experiment Video

Updated: Aug 12, 2025

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

7.4K

Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window.

Alicia N Vagnozzi1, Matthew T Moore1, Raquel López de Boer1

  • 1Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.

Biorxiv : the Preprint Server for Biology
|January 30, 2023
PubMed
Summary

Catenin signaling is crucial for the development of phrenic motor column (PMC) neurons, essential for breathing. However, these catenins are not required for maintaining PMC neuron function after development.

More Related Videos

Retrograde Neuroanatomical Tracing of Phrenic Motor Neurons in Mice
09:05

Retrograde Neuroanatomical Tracing of Phrenic Motor Neurons in Mice

Published on: February 22, 2018

12.8K
Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
06:08

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Published on: April 19, 2024

481

Related Experiment Videos

Last Updated: Aug 12, 2025

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

7.4K
Retrograde Neuroanatomical Tracing of Phrenic Motor Neurons in Mice
09:05

Retrograde Neuroanatomical Tracing of Phrenic Motor Neurons in Mice

Published on: February 22, 2018

12.8K
Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
06:08

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Published on: April 19, 2024

481

Area of Science:

  • Neuroscience
  • Developmental Biology

Background:

  • Phrenic motor column (PMC) neurons innervate the diaphragm, vital for respiration.
  • Mechanisms governing phrenic motor neuron development and function remain incompletely understood.

Approach:

  • Investigated the role of catenin-mediated cadherin adhesion in phrenic motor neuron development.
  • Utilized genetic deletion of β- and γ-catenin in motor neuron progenitors and postmitotic neurons.

Key Points:

  • Catenin deletion in motor neuron progenitors caused perinatal lethality and impaired phrenic motor neuron activity.
  • Loss of catenins disrupted phrenic motor neuron topography, clustering, and axonal/dendritic growth.
  • Catenins are essential for early phrenic motor neuron development but dispensable for maintenance.

Conclusions:

  • Catenins play a fundamental role in phrenic motor column development.
  • Distinct mechanisms likely regulate phrenic motor neuron maintenance versus development.