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Updated: Aug 12, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Optimizing the interpretation of Clostridioides difficile two-step diagnostic algorithm results through antimicrobial
Christopher F Lowe1,2,3, Shayan Shakeraneh3, Colin Lee4
1Pathology and Laboratory Medicine, Providence Health Care, Vancouver, British Columbia, Canada.
Abstract:
Over a 4-year period, the antimicrobial stewardship team reviewed all positive (PCR+/Tox+) and indeterminate (PCR+/Tox-) cases with the most responsible physician for classification of patients as infection or colonization. Among 501 indeterminate samples, 213 (43%) were considered to be clinical infection, suggesting the need for ongoing clinical assessment of indeterminates.
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