Crosstalk between microwave ablation and ferroptosis: The next hot topic?

Area of Science:

• Oncology
• Biochemistry
• Medical Physics

Background:

• Microwave ablation (MWA) is a thermal ablation technique for local tumor control.
• Ferroptosis is a form of regulated cell death characterized by iron accumulation and lipid peroxidation.
• Emerging evidence suggests ferroptosis plays a role in MWA's tumor suppression effects.

Purpose of the Study:

• To review the concept and pathways of ferroptosis.
• To explain the principles of MWA in tumor treatment.
• To explore the interplay between MWA and ferroptosis for enhanced antitumor effects.

Main Methods:

• Literature review of ferroptosis and MWA.
• Analysis of signaling pathways involved in MWA-induced ferroptosis.
• Discussion of cross-talking molecules and therapeutic targets.

Main Results:

• MWA induces tumor cell death, potentially through ferroptosis.
• Key molecules released during MWA may interact with ferroptosis pathways.
• Ferroptosis inducers could enhance MWA's systemic antitumor efficacy.

Conclusions:

• MWA-induced ferroptosis is a potential mechanism for tumor suppression.
• Targeting ferroptosis offers a strategy to augment MWA therapy.
• Combining MWA with pro-ferroptosis treatments may improve systemic antitumor responses.