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Optical Trapping of Nanoparticles
Published on: January 15, 2013
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Advances in upconversion luminescence nanomaterial-based biosensor for virus diagnosis
Yingjin Ma1, Menglin Song1, Lihua Li1
1Department of Applied Physics The Hong Kong Polytechnic University Hong Kong China.
Exploration (Beijing, China)
|January 30, 2023
Summary
Upconversion nanoparticles (UCNPs) offer advanced biosensors for rapid virus detection. This review highlights UCNP-based strategies enhancing sensitivity and providing a promising alternative for pathogen detection.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Infectious Disease Diagnostics
Background:
- Infectious viruses, including SARS-CoV-2, represent a significant global public health threat.
- Rapid and reliable pathogen detection methods are crucial for disease control.
- Upconversion nanoparticles (UCNPs) possess unique properties advantageous for biosensor development.
Purpose of the Study:
- To review recent advancements in upconversion nanoparticle-based (UCNP) biosensors for detecting viruses and biomarkers.
- To summarize design principles and underlying mechanisms of UCNP biosensors.
- To discuss the benefits, challenges, and future directions of UCNP applications in virus bioassays.
Main Methods:
- Summary of four fundamental design principles for UCNP-based biosensors.
- Analysis of luminescent or electric responses as output signals.
- Review of strategies to enhance biosensor sensitivity.
Main Results:
- UCNP-based biosensors demonstrate significant potential for sensitive virus detection.
- Various bioassays benefit from the application of UCNPs.
- Identified obstacles and suggested future research pathways.
Conclusions:
- UCNP-based biosensors offer a convenient and effective alternative for virus detection.
- Continued research can further establish UCNPs as a prominent tool in diagnostics.
- Advancements in UCNP technology promise improved global health security.
