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Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
Published on: April 25, 2025
292
Benign lesions with 68Ga-FAPI uptake: a retrospective study
Qiaoqiao Shu1,2,3, Yudi Wang1,2,3, Maoxue Deng1,2,3
1Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
The British Journal of Radiology
|January 30, 2023
Summary
Fibroblast activation protein (FAPI) imaging can identify benign lesions, not just malignant tumors. Physicians should be aware of FAPI uptake in benign conditions to avoid misdiagnosis.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiology
Background:
- Fibroblast activation protein (FAPI) is a pan-tumor tracer with high expression in malignant imaging.
- FAPI uptake has also been observed in certain benign lesions, posing diagnostic challenges.
Purpose of the Study:
- To retrospectively analyze the characteristics of benign lesions exhibiting FAPI uptake on 68Ga-FAPI PET/CT imaging.
Main Methods:
- Retrospective analysis of electronic medical and imaging records from March 2020 to March 2022.
- Inclusion of patients with benign lesions confirmed by histopathology or long-term follow-up of FAPI-positive lesions.
Main Results:
- 44 benign lesions across eight systems were analyzed in 44 patients (14 women, 30 men; age 19-74).
- No significant differences were found in mean SUVmax (p=0.471) and mean TBR (p=0.830) between benign lesions in different systems.
Conclusions:
- Benign lesions can exhibit FAPI expression, necessitating careful differentiation from malignant tumors.
- Physicians must be aware of FAPI uptake in benign conditions to aid in differential diagnosis.
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