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Covalent Organic Frameworks: Recent Progress in Biomedical Applications.

Yongqiang Shi1,2, Jinglun Yang2, Feng Gao1

  • 1Key Laboratory of Functional Molecular Solids, Ministry of Education, and Anhui Key Laboratory of Chemo/Biosensing, Laboratory of Biosensing and Bioimaging (LOBAB), and School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241002, China.

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Summary
This summary is machine-generated.

Covalent organic frameworks (COFs) show great potential in biomedical applications due to their unique porous structure and biocompatibility. This review highlights COF advancements in drug delivery, bioimaging, and therapy, discussing future directions.

Keywords:
biocompatibilitybioimagingbiomedical applicationsbiosensingcovalent organic frameworksdrug deliverygene deliveryphotodynamic thermal treatment

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Covalent organic frameworks (COFs) are crystalline porous materials with tunable properties.
  • COFs possess advantageous characteristics like high surface area, porosity, and biocompatibility.
  • Recent research highlights COFs as promising candidates for diverse biomedical applications.

Purpose of the Study:

  • To review recent advancements in the application of COFs in various biomedical fields.
  • To discuss the potential of COFs in photodynamic therapy, gene delivery, drug delivery, bioimaging, biosensing, and combined therapies.
  • To identify critical challenges and future perspectives for COFs in biology-facing applications.

Main Methods:

  • Literature review of recent studies on COF materials in biomedical applications.
  • Analysis of COF properties relevant to biological systems.
  • Synthesis and characterization of COFs for therapeutic and diagnostic purposes (as reported in cited literature).

Main Results:

  • COFs demonstrate significant potential in drug delivery systems, enhancing therapeutic efficacy.
  • COFs show promise in bioimaging and biosensing due to their unique optical and electronic properties.
  • COFs are effective in photodynamic and photothermal therapies, offering new treatment modalities.

Conclusions:

  • COFs are versatile materials with broad applicability in advanced biomedical applications.
  • Further research is needed to overcome challenges related to COF stability, scalability, and in vivo translation.
  • COFs are poised to play a significant role in the future of nanomedicine and personalized healthcare.